With the ratification of Multilateral Environmental Agreements the countries of the international community or of intentional communities—be they political, economic, financial, securitarian or strategic—endow these instruments of international cooperation with significant autonomy. From the 3550 dates of ratification of these MEAs recorded from 1979 to mid-September 2014, we produce a graph whose vertices are the 48 MEAs and whose links are induced by the succession of ratifications in time. On this basis we propose a diagnosis on the international acceptance of (...) this type of legal instruments and their vulnerability in a global context that builds on the change in the balance of powers as a result of globalization, the break of the bipolar and then unipolar system, and the rise of new powers. Thus, it appears that a global environmental order has been promoted and implemented with some success in the 90s mainly by liberal Western countries who were then able to lead other countries less likely to bind to the fulfillment of environmental obligations. However, the expansion of this global environmental order now seems frozen, due to the current crisis of multilateralism. The rise of many countries, particularly in the South, whose environmental, political and economic weight grew, confronted with the “stable community” formed in the past 35 years suggests that there is a real power shift in the international arena and consequently, multilateralism needs to reflect this new reality. In other terms, the global environmental order is being slowly reformed. As a consequence, the treaties formed clusters in the past but they did not follow the same pattern since the twenty-first century began. (shrink)

O atual trabalho se debruça sobre o instituto do refúgio por um prisma jusfilosófico, significa a construção dos ditames jurídicos constituídos por uma via filosófica que permite uma pluralidade de oportunidade para concepção de possíveis soluções a partir de uma metodologia explicativa e do método de pesquisa bibliográfica. Os objetivos da pesquisas são: perscrutar a relação entre justiça e direito, compreender o conceito do refúgio jurídico, estudar o fenômeno do refúgio pelos conceitos de alteridade e hospitalidade do filósofo Derrida, analisar (...) se os refugiados são acolhidos a partir de uma ótica da hospitalidade. (shrink)

O presente trabalho visa compreender as contribuições de Warat para uma visão nãoengessada do ensino jurídico. Trata-se de analisar a dogmática jurídica a partir de uma desconstrução que se dá no entrelaçamento entre Direito e Arte, perpassando pelo amor. Há ainda uma necessidade de ter uma cosmovisão para transformar a dogmática jurídica em um ensino jurídico plural, para isso é necessário sair da ordem (cosmos) e encontrar a desordem (caos) e o professor tem papel fundamental nessa transformação, pois este seduz (...) e liberta. Essa didática libertadora é conduzida por uma concepção diferenciada entre razão e emoção. (shrink)

O presente trabalho visa uma reflexão interessada do pensamento de Luis Alberto Warat sobre a égide do ensino jurídico, trata-se de uma releitura da obra A Ciência Jurídica e seus dois maridos, onde aborda o imaginário carnavalizado. Essa proposta nasce motivada dos conceitos e desconstruções feitas pelo autor em epígrafe. Trata-se de analisar a dogmática jurídica a partir de uma desconstrução que se dá no entrelaçamento entre Direito e Arte, perpassando pelo amor tendo como método o surrealismo jurídico. Essa didática (...) libertadora é conduzida por uma concepção diferenciada entre razão e emoção. (shrink)

Background Studying global health problems requires international multidisciplinary teams. Such multidisciplinarity and multiculturalism create challenges in adhering to a set of ethical principles across different country contexts. Our group on health system responses to violence against women (VAW) included two universities in a European high-income country (HIC) and four universities in low-and middle-income countries (LMICs). This study aimed to investigate professional and policy perspectives on the types, causes of, and solutions to ethical challenges specific to the ethics approval stage of (...) the global research projects on health system responses to VAW. Methods We used the Network of Ethical Relationships model, framework method, and READ approach to analyse qualitative semi-structured interviews (n = 18) and policy documents (n = 27). In March-July 2021, we recruited a purposive sample of researchers and members of Research Ethics Committees (RECs) from the five partner countries. Interviewees signposted policies and guidelines on research ethics, including VAW. Results We developed three themes with eight subthemes summarising ethical challenges across three contextual factors. The global nature of the group contributed towards power and resource imbalance between HIC and LMICs and differing RECs’ rules. Location of the primary studies within health services highlighted differing rules between university RECs and health authorities. There were diverse conceptualisations of VAW and vulnerability of research participants between countries and limited methodological and topic expertise in some LMIC RECs. These factors threatened the timely delivery of studies and had a negative impact on researchers and their relationships with RECs and HIC funders. Most researchers felt frustrated and demotivated by the bureaucratised, uncoordinated, and lengthy approval process. Participants suggested redistributing power and resources between HICs and LMICs, involving LMIC representatives in developing funding agendas, better coordination between RECs and health authorities and capacity strengthening on ethics in VAW research. Conclusions The process of ethics approval for global research on health system responses to VAW should be more coordinated across partners, with equal power distribution between HICs and LMICs, researchers and RECs. While some of these objectives can be achieved through education for RECs and researchers, the power imbalance and differing rules should be addressed at the institutional, national, and international levels. Three of the authors were also research participants, which had potential to introduce bias into the findings. However, rigorous reflexivity practices mitigated against this. This insider perspective was also a strength, as it allowed us to access and contribute to more nuanced understandings to enhance the credibility of the findings. It also helped to mitigate against unequal power dynamics. (shrink)

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 − the “plunger” − pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex − the “barrel” − into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the “barrel” is an ATP-independent process, whereas extraction (...) of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model. The peroxin PEX5 is the peroxisomal matrix protein receptor. It shuttles between the cytosol and the organelle membrane, where it gets inserted into the docking/translocation module, thus pushing the cargo-protein into the peroxisome lumen. Resetting the system involves PEX5 monoubiquitination and its extraction from the membrane by the AAA-ATPases, PEX1/PEX6. (shrink)

O artigo visa a analisar como a Psicologia tem encarado os desafios colocados pelo desempenho escolar. Discute os princípios e as ferramentas q ue têm orientado as práticas psicológicas no campo do fracasso escolar. Faz um debate acerca da interface Psicologia e Educação, partindo dos princípios da ..

Este artigo pretende analisar as interfaces da produção científica feminina no início do século XX com a constituição do espaço psi no Brasil, utilizando para tanto um artigo do periódico católico "A Ordem" e uma tese da Faculdade de Medicina do Rio de Janeiro. Para sermos mais precisos, nosso recor..

Estudo comparado sobre o tratamento dado à reprodução humana assistida no direito do Brasil, Estados Unidos, Portugal, Espanha e Itália.

High blood pressure (HBP) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP), and the presence of elevated BP in childhood is predictor of hypertension in adult life. Studies have shown a positive correlation between sodium chloride ingested in the diet and blood pressure values. This study aims to evaluate the consumption of added salt before and after awareness of risk, by high school students. This occurred for three days in the refectory, where students (...) received illustrative brochure with information about sodium intake; exhibition of a poster illustrating foods with their respective equivalent amount of sodium and sodium chloride, exemplifying the maximum recommended amount of consumption per day. For five days, before and after gaining awareness, it the amount of consumption of sachets of salt was accounted. Statistical analyzes were performed by Student's Test, with a confidence interval of 95%. During the study period were served on average 128.3 meals. Before the awareness of sodium consumption of risks, of 820mg and 330mg sodium salt was consumed an average per individual, and thereafter, 640mg and 260mg, respectively (p=0,043). Simple Nutrition Education Strategies in short term were effective for improving the consumption of added salt in adolescents. (shrink)

Este trabalho é parte de um estudo etnográfico em andamento no mestrado em Relações Étnicas e Contemporaneidade, período entre 2015-2017 com crianças da Comunidade Quilombola Barroso, município de Camamu-Bahia. Para construção dos dados foram realizadas pesquisas de campo, análises documentais, leituras de periódicos, livros e pesquisas online. Durante as observações pretendeu-se investigar como se dá o processo de construção identitária das crianças, tendo como objetivos específicos conhecer como os estudantes expressam sua identidade na escola e analisar de que forma as (...) relações estabelecidas na escola influenciam na construção identitária das crianças. Para além da escola, visitamos outros espaços por considerar importante e necessário conhecer como elas se relacionam, direcionando este primeiro olhar para o contexto sócio-histórico, político e cultural da comunidade. Palavras chave: Identidade. Quilombo. Símbolo. (shrink)

This study aimed to evaluate the food production and then act to increase the quality and security of a service, in order to meet the requirements for qualification HAPPC, using good manufacturing procedures as starting point for implementation. It is characterized as an intervention study, emphasizing the quality of foods and the use of good manufacturing procedures at the foodservice and nutrition units, located in Botucatu-SP. It was composed of 2 moments. In the first, we applied a check-list for ascertainment (...) of non-conformity and in the second moment a training “in loco” was given for the collaborators. The lack of hygienic cleaning of hands is seen as an important negative point. We verified that the biggest difficulties and irregularities are related to the manipulators which don´t follow the rules. Good manufacturing procedures were obtained to increase the quality and the security of foods in the unit, but these must be kept constantly adjusted to the standards. (shrink)

AimThe aim of our study was to analyze physical activity levels, sitting time, physical fitness, and their relationship with depressive symptoms after home confinement in previously active older adults.MethodsThis cross-sectional study sample comprised 68 older adults from a community-based exercise program conducted in Porto, Portugal. After home confinement, participants were assessed in person for lower-body strength, cardiorespiratory fitness, agility/dynamic balance, handgrip strength, and anthropometry. Telephone interviews were performed to evaluate depressive symptoms with the Geriatric Depression Scale – 15 items and (...) physical activity levels through the International Physical Activity Questionnaire. Individuals were also asked to self-report changes in their physical activity levels and time spent sitting.ResultsNinety percent of older adults self-reported a decrease in overall physical activity levels, and nearly 65% increased daily sitting time during the home confinement. However, previously active older adults still presented high levels of physical fitness after 11 weeks of home confinement. Overall, 52.9% of participants scored 5 or more points on GDS-15, which is suggestive of depression. Higher levels of moderate-to-vigorous physical activity and cardiorespiratory fitness were found in the non-depressed group compared with the depressed group. Finally, results from multiple regression analysis revealed that MVPA was negatively associated with depression. This model explained 16.4% of the variability seen in depression score, controlled for age, gender, and education.ConclusionEven reporting a decline in physical activity, older adults who previously participated in a formal exercise program, still presented high levels of physical fitness after 11 weeks of home confinement. However, MVPA, but not physical fitness, seems to be an associated depression score in previously active older adults. These results reinforce the importance of older adults to remain physically active, since higher levels of MVPA may have a protective effect on depressive symptoms and, therefore, mitigate the negative impact of home confinement on mental health. Future longitudinal research studies are needed to ascertain these results. (shrink)

A evolução dos meios de comunicação propiciou um massivo fluxo informacional, trazendo consigo alguns entraves. O fenômeno das fake news é produto dessa mudança na sociedade, afetando de diversas formas a vida das pessoas e inclusive a possibilidade de uma escolha plena e livre de influências, sua liberdade de expressão, pensamento e informação. Nesse contexto, este evento se torna gravoso para o nosso Estado Democrático, na medida que influencia o comportamento, as escolhas políticas, a conduta social e a solidez da (...) própria democracia. Diante do exposto, o objetivo do presente trabalho é refletir como as fake news interferem no Estado Democrático de Direito no Brasil e o deformam. Trata-se de uma revisão bibliográfica, documental e qualitativa. Propõe-se, por meio desse estudo, explicitar o que é esse fenômeno tão complexo das fake news e compreender as diversas formas de como ele pode afetar nosso sistema democrático, baseando-se nas ideias discursivas de Habermas. (shrink)

IntroductionRegular exercise has long been shown to positively impact the immune system responsiveness and improve mental well-being. However, the putative links between biomarkers of mental health and immune efficiency in exercising subjects have been scarcely investigated. The aim of this study was to verify the effect of a 14-week combined chair-based exercise program on salivary steroid hormones and anti-microbial proteins, functional fitness, and MWB indexes in pre-frail older women.MethodsThe participant women were randomly divided into the exercising group and the non-exercising (...) control group. The pre/post assessment included: salivary anti-microbial proteins lysozyme; and immunoglobulin-A ; salivary steroid hormones of testosterone and cortisol ; functional fitness ; MWB questionnaires.ResultsSignificant differences with large Cohen’s effect sizes were found on increased salivary TT after exercise intervention. The results revealed a decrease in IgA levels after CEP. The increase in subjective happiness levels and decrease of stress perception and depressive state were found after intervention in the CEP group. Robust statistical differences in gait speed and balance tests were also found in the CEP group. In control, COR increased moderately while no changes were found for the other indicators. Correlation analyses showed inter-dependence between pre–post variations of MWB, biochemical indexes, and fitness function.ConclusionThe CEP program was able to improve functional-fitness performance, decrease feelings of stress, and increase happiness. The CEP also induced clinically relevant hormonal and immune responses, which suggests that chair exercises that combine muscular strength, balance, and gait speed training are promising interventions to improve physical and mental health of older pre-frail adults. (shrink)

Na tentativa de propor uma conciliação das práticas comunitária e clínica em Psicologia, pretendemos desenvolver os seguintes elementos em ambas as propostas: uma prática de escuta às situações emergentes, uma postura ética e política de escuta aos sujeitos e a promoção da saúde engajada na realidade social brasileira. Ambas as perspectivas podem ser complementares desde que partamos da unidade e não da dicotomia entre elas. Defendemos que as propostas de Psicologia Comunitária, inaugurada por Martin-Baró, e de Psicologia Clínica em uma (...) perspectiva fenomenológico-existencial, inaugurada por Binswanger, prescindem da necessidade de se excluírem mutuamente visto que ambas partem da concepção de comunidade como elemento unificador do binômio ser e mundo. Apostamos na construção de práticas ético-políticas pela necessidade de se promover uma união entre clínica e comunidade, entre natureza humana e social, tal como defendidas por Krenak e Kopenawa. E ainda, dando voz à cultura brasileira e em uma defesa do movimento Modernista, dialogamos com Oswald de Andrade, Clarice Lispector, Manoel de Barros, Manoel Bandeira, Rubem Alves e Guimarães Rosa. Em conclusão, a proposta é de que a clínica psicológica na perspectiva do nós se estabelece como processo sociopolítico de injunção dos assujeitados, resistência à massificação e a derrocada do poder do impessoal no gerenciamento da vida. (shrink)

Evidence is accumulating that individual and environmental factors in childhood and adolescence should be considered when investigating adult health and aging-related processes. The data required for this is gathered by comprehensive long-term longitudinal studies. This article describes the protocol of the Zurich Longitudinal Studies, a set of three comprehensive cohort studies on child growth, health, and development that are currently expanding into adulthood. Between 1954 and 1961, 445 healthy infants were enrolled in the first ZLS cohort. Their physical, motor, cognitive, (...) and social development and their environment were assessed comprehensively across childhood, adolescence, and into young adulthood. In the 1970s, two further cohorts were added to the ZLS and assessed with largely matched study protocols: Between 1974 and 1979, the second ZLS cohort included 265 infants, and between 1970 and 2002, the third ZLS cohort included 327 children of participants of the first ZLS cohort. Since 2019, the participants of the three ZLS cohorts have been traced and invited to participate in a first wave of assessments in adulthood to investigate their current health and development. This article describes the ZLS study protocol and discusses opportunities, methodological and conceptual challenges, and limitations arising from a long-term longitudinal cohort recruited from a study about development in early life. In the future, the ZLS will provide data to investigate childhood antecedents of adult health outcomes and, ultimately, will help respond to the frequent call of scientists to shift the focus of aging research into the first decades of life and, thus, to take a lifespan perspective on aging. (shrink)

The Operation Lava Jato, initiated in 2014 by the Ministry of Finance and carried out by the Brazilian Government Agency for Law Enforcement and Prosecution of Crimes, brought to light the unethical practices of several national contractors, despite their declared commitment to social responsibility and ethical management—a corporate conduct epitomized in the popular saying: “Do what I say; don’t do what I do”. In this chapter, we analyze such disconnection between discourse and practice vis-a-vis the literature on leadership and business (...) ethics, Brazilian culture and historical analyses of the Brazilian contractors industry. We examine the official discourse of a Brazilian contractor, as observed in documents retrieved from websites and statements to the press, and its practices, as depicted in the media and documented in testimonies already conducted by the federal courts and attached to the original case-files. Specifically, we aim to contribute to the reflection on management and ethics in Brazil by identifying and discussing the factors that seem to have promoted such disconnection, including aspects of national culture and the institutional environment, together with organizational culture and leadership. (shrink)

This paper presents an intuitive explanation about why and how Rawlsian Theory of Justice (Rawls in A theory of justice, Harvard University Press, Harvard, 1971) provides the foundations to a solution for algorithmic bias. The contribution of the paper is to discuss and show why Rawlsian ideas in their original form (e.g. the veil of ignorance, original position, and allowing inequalities that serve the worst-off) are relevant to operationalize fairness for algorithmic decision making. The paper also explains how this leads (...) to a specific MinMaxfairness solution, which addresses the basic challenges of algorithmic justice. We combine substantive elements of Rawlsian perspective with an intuitive explanation in order to provide accessible and practical insights. The goal is to propose and motivate why and how the MinMaxfairness solution derived from Rawlsian principles overcomes some of the current challenges for algorithmic bias and highlight the benefits provided when compared to other approaches. The paper presents and discusses the solution by building a bridge between the qualitative theoretical aspects and the quantitative technical approach. (shrink)

(Spanish) RESUMEN: La libertad absoluta postulada por Viktor Emil Frankl y Jean-Paul Sartre, la Shoah y la creencia en un dios omnipotente, bueno y justo parecen contradecirse. La pregunta por el sentido del sufrimiento de las víctimas del Holocausto (la verdadera catástrofe, el mayor crimen contra la humanidad), simbolizado por Auschwitz, y como punto de inflexión en la historia, es terriblemente dolorosa y parece no tener una respuesta filosófica ni teológica. A mi juicio, es importantísimo distinguir entre las víctimas inocentes (...) de la Shoah que perecieron y las víctimas inocentes que sufrieron un verdadero infierno y perdieron a sus seres queridos, pero que lograron sobrevivir. Ambas son víctimas, por supuesto, pero así como encontrarle un posible sentido al sufrimiento de las víctimas masacradas y gaseadas podría suponer un insulto a su sufrimiento y agonía –en especial, al horror que sufrieron los niños–, el horrible sufrimiento de los supervivientes pudo dar, tal vez, de alguna manera, un sentido a sus vidas después de la liberación de los campos de concentración y exterminio, ya fuera como voz, como protesta o como simple supervivencia. Frankl apuesta por un sentido último (que abraza el sentido del sufrimiento de las víctimas), y Sartre, aunque parezca no apostar por sentido alguno, volcó su vida al compromiso político después de la Segunda Guerra Mundial, y ello parece vislumbrar una minúscula pizca de sentido después de la barbarie. La filosofía de Frankl es un sí a la vida incluso en las situaciones más extremas, un grito casi nietzscheano que exalta el valor de la vida más allá de cualquier sufrimiento. Frankl, padre de la logoterapia y superviviente del Holocausto, abre una puerta a Dios al hablar de un dios inconsciente, una dimensión suprahumana y una fe incondicional, y define la religión como espiritualidad y como la búsqueda del hombre por el sentido último. Según Frankl, la libertad no se contradice con Dios, y la religión existe no a raíz de la barbarie, sino a pesar de la barbarie. El existencialismo sartreano es una filosofía de la libertad radical y de la responsabilidad. El hombre está condenado a ser libre. El ser humano es un ser en el que la existencia precede a la esencia. Somos totalmente responsables de lo que somos. Sartre afirma que la libertad humana es incompatible con Dios. En un mundo sin Dios, la moral la construyen los hombres, con sus propias decisiones y sus acciones, y la existencia y el sufrimiento de las víctimas no tienen sentido alguno. Sartre define al hombre como libertad, responsabilidad, angustia y contingencia. Frankl define al hombre como libertad, responsabilidad, espiritualidad y búsqueda de sentido. Con esta tesis me propongo entrar en la resbaladiza dimensión del dolor, la desesperación, el sentido y sinsentido del sufrimiento de las víctimas (teniendo presente los horrores de Auschwitz, que en teología y filosofía ha simbolizado desde la liberación de los campos la muerte de Dios y la muerte de la moral). Es verdad que no solo los hombres, mujeres y niños judíos fueron víctimas de la barbarie alemana, pero, como reza el mensaje de Elie Wiesel en la exposición permanente del Block 27 del Auschwitz-Birkeanu State Museum: "Not all victims were Jewish in this place, but all Jews were victims". La Shoah no es un episodio dentro de la Segunda Guerra Mundial, sino un punto de inflexión en la historia de la humanidad, y es una catástrofe que nos concierne a todos, hombres y mujeres judíos y no judíos, religiosos e irreligiosos, creyentes e increyentes, como seres libres, responsables y morales que somos –o que deberíamos ser. Muchas de las víctimas del Holocausto, en medio de la desesperación, entraron en las cámaras de gas orando, aferrándose a la esperanza de que ese final espeluznante no era un punto final. Con esta tesis no me propongo de ninguna manera responder a la eterna pregunta de si Dios existe o no, sino que propongo interpretar ese grito hacia Dios como un desesperado anhelo de esperanza. También me propongo encontrar una coherencia en las posturas de estos dos grandes pensadores para quienes la libertad y la responsabilidad definen al hombre: Frankl (quien apuesta por una dimensión suprahumana donde existe un sentido último en el que el sufrimiento de las víctimas tiene que tener algún sentido, aunque ese sentido sea completamente incomprensible en la dimensión humana) y Sartre (el existencialista ateo por excelencia, para quien el mundo, la existencia y el sufrimiento son absolutamente contingentes). En el primer capítulo expongo la logoterapia y el existencialismo sartreano: describo las tres dimensiones del hombre y las tres búsquedas de sentido propuestas por Frankl, y expongo las cinco consecuencias de "l'existence précède l'essence", centrándome en la libertad y la responsabilidad, y hablo del suicidio. El segundo capítulo está dedicado al dios inconsciente frankleano, la dimensión suprahumana, la búsqueda por el sentido último y la fe incondicional. En el tercer capítulo ilustro la libertad sin Dios sartreana, la ontología sartreana, el ateísmo sartreano y el humanismo sartreano, y hablo sobre la responsabilidad, la mauvaise foi, la contingencia, la situation y la angustia. El cuarto capítulo es necesariamente histórico (sin dejar de ser filosófico): me pregunto por la muerte de Dios después de Auschwitz, argumento y defiendo la unicidad del Holocausto (la Shoah es un punto de inflexión en la historia de la humanidad), describo las masacres antes de los campos de exterminio (Einsatzgruppen, Ordnungspolizei y Wehrmacht), el gigantesco complejo de Auschwitz (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), reflexiono sobre Dios y el mal (centrándome en los niños de Auschwitz), describo los días de Frankl en Auschwitz, hablo de Dios como esperanza, de la inmortalidad y la escatología, de la crueldad de Dios, de la relación entre el cristianismo y el antisemitismo, del islam y el antisemitismo, critico el silencio de Dios, hablo de la muerte de Dios y del juicio contra Dios. En el quinto capítulo expongo la moral frankleana (una moral que atañe al hombre y no a Dios), basándome en su teoría del amor y en su única obra de teatro (Synchronisation in Binkerwald), y la moral sartreana (una moral que atañe a una humanidad sin Dios), recordando a Dostoyevsky, analizando la famosa cita de Garcin en Huis clos "L'enfer, c'est les Autres", criticando el marxismo de Sartre y cuestionando (con la mirada de Frankl y Sartre) el verso de Brecht "Erst kommt das Fressen, dann kommt die Moral"; al final del capítulo incluyo una reflexión propia y las críticas frankleana y sartreana sobre la impunidad de los verdugos y colaboradores después del Holocausto (con el permiso de Dios). Después de la Conclusión, añado un Apéndice sobre las vidas de Frankl y Sartre, para poder entender mejor su obra. PALABRAS CLAVE: logoterapia, existencialismo sartreano, búsqueda de sentido, libertad, responsabilidad, moral, angustia, sufrimiento, supervivientes, víctimas, contingencia, espiritualidad, religión, Dios, esperanza, antisemitismo, culpa, Auschwitz, Holocausto, Shoah. /// (English) ABSTRACT: The absolute freedom defended by Viktor Emil Frankl and Jean-Paul Sartre, the Shoah and the belief in an omnipotent, benevolent and just God seem to contradict each other. The question of the meaning of the victims' suffering of the Holocaust (the true catastrophe, the biggest crime against humanity), simbolised by Auschwitz and as a turning point in History, is terribly painful and doesn't seem to have an answer. In my opinion, it's crucial to distinguish between the innocent victims of the Shoah who perished and the innocent victims who sufferend a real hell and lost their loved ones, but managed to survive. Both are victims, of course, but just as finding a possible meaning to the suffering of the massacred and gassed victims could result in an insult to their suffering and agony –especially to the horror that the children suffered– the gigantic suffering of the survivors could, maybe, somehow, give a meaning to their lives after the liberation of the concentration and extermination camps, either as a voice, as a protest, or as a simple survival. Frankl believes in an ultimate meaning (that embraces the meaning of the victims' suffering), and Sartre, even if it appears not to embrace any meaning, turned his life to political engagement after War World II, and that attitude seems to give a tiny glimpse of meaning after the barbarity. Frankl's philosophy says yes to life even in the most extreme situations, and it's a Nietzschean-like scream that exalts the value of life beyond any monstrous suffering. Frankl, the father of logotherapy and a Holocaust survivor, opens a door to God when he talks about an unconscious God, a supra-human dimension and an unconditional faith; he defines religion as spirituality and as man's search for ultimate meaning. According to Frankl, freedom is not contradictory with God, and religion exists not because of the barbarity but in spite of the barbarity. Sartrean existentialism is a philosophy of radical freedom and responsibility. Men are condemned to be free. We are beings where the existence precedes the essence. We are completely responsible of what we are. Sartre argues that human freedom is incompatible with God. In a godless world, morality is constructed by people, with their own choices and actions, and human existence and the suffering of the victims don't have any meaning. Sartre defines man as freedom, responsibility, Angst and contingency. Frankl defines man as freedom, responsibility, spirituality and search for meaning. With this dissertation I attempt to enter in the slippery dimension of the pain, despair, meaning and meaninglessness of the victims' suffering (having in mind the horrors of Auschwitz, that in theology and in philosophy have simbolised, since the liberation of the camps, the death of God and the death of morality). It's true that not only Jewish men, women and children were victims of the German barbarity, but, as Elie Wiesel's message from the permanent exhibition from Block 27 of the Auschwitz-Birkeanu State Museum reads: "Not all victims were Jewish in this place, but all Jews were victims". The Shoah is not an episode inside War World II, but a turning point in the history of humankind, and a catastrophe that embraces us all, Jewish and not not Jewish men and women, religious and not religious, believers and not believers, as the free, responsible and moral beings that we all are –or that we should be. A lot of the victims, in the midst of their desperation, entered into the gas chambers praying, holding to the hope that their horrifying end was not the ultimate end. With this dissertation I do not attempt to answer the eternal question of the existence of God, rather, I will try to interpret that scream to God as a longing for hope. I also intend to find a coherence between the thought of these two great thinkers for whom freedom and responsibilty define man: Frankl (who argues that there is a suprahuman dimension where an ultimate meaning exists and where the victims' suffering has to have a meaning, even if this meaning is completely incomprehensible in the human dimension) and Sartre (the atheist existentialist par excellence, for whom the world, human existence and suffering are absolutely contingent). In the first chapter I expose logotherapy and Sartrean existentialism: I describe the three dimensions of man, the three searches for meaning, the five consequences of "l'existence précède l'essence" and I speak about suicide. The second chapter delves into the unconscious God, the supra-human dimension, the ultimate meaning and the unconditional faith. In the third chapter I expose the freedom without God defended by Sartre, Sartre's ontology, Sartre's atheism, Sartre's humanism, and his ideas about responsibility, mauvaise foi, contingency, situation, and Angst. The fourth chapter is necessarily historical (while being philosophical too): I wonder about the death of God after Auschwitz, I argue and defend the uniqueness of the Holocaust (the Shoah is a turning point in the history of humankind), I describe the massacres before the extermination camps (Einsatzgruppen, Ordnungspolizei y Wehrmacht), the gigantic Auschwitz camp complex (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), I reflect on God and evil (focusing on the children of Auschwitz), I describe Frankl's days in Auschwitz, I talk about God as hope, about immortality and escathology, I discuss God's cruelty, the relationship between Christianity and antisemitism and Islam and antisemitism, I question the silence of God, and I talk about the death of God and about the trial against God. In the fifth chapter I talk about the Franklean morality (a morality that concerns man and not God), on the basis of his love theory and his only work of theater (Synchronisation in Binkerwald), and the Sartrean morality (a morality that concerns a humanity without God), remembering Dostoyevsky, analysing Garcin's famous quote in Huis clos "L'enfer, c'est les Autres", crticizing Sartre's marxism and questioning (with Frankl's and Sartre's eyes) Brecht's verse "Erst kommt das Fressen, dann kommt die Moral"; at the end of the chapter I include my own reflection (and Frankl and Sartre's critique) about the impunity of the executioners and collaborators after the Holocaust (with God's permission). After the Conclusion, I add an Appendix about the lives of Frankl and Sartre, which helps understanding better their work. KEYWORDS: logotherapy, existentialism, search for meaning, freedom, responsibility, morality, Angst, suffering, survivors, victims, contingency, spirituality, religion, God, hope, antisemitism, guilt, Auschwitz, Holocaust, Shoah. (shrink)

Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned. Since its discovery in 1985, it has been used by us and by many laboratories around the world as an invaluable marker to study the distribution of synapses in the brain and to uncover the basic features of the life cycle of SVs. Although single gene ablation of Syp does not lead to an overt phenotype, a large body of experimental data both in vitro and in vivo indicate (...) that Syp (alone or in association with homologous proteins) is involved in multiple, important aspects of SV exo‐endocytosis, including regulation of SNARE assembly into the fusion core complex, formation of the fusion pore initiating neurotransmitter release, activation of SV endocytosis and SV biogenesis. In this article, we summarise the main results of the studies on Syp carried out by our and other laboratories, and explain why we believe that Syp plays a major role in SV trafficking. BioEssays 26:445–453, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This paper is the result of my participation in a discussion event of Problema. Anuario de filosofía y teoría del derecho entitled “The Construction of Precedent in Civil Law: Debates, Concepts and Challenges”. Several colleagues with a vast knowledge on the subject of judicial precedent participated in this seminar, which also delved into the widely debated aspects of judicial precedent focused on the case of Chile. The entire discussion aimed at proposing solutions, as well as shedding some light on some (...) of its important aspects.Starting from such transcendental concepts as, rationality and argumentative use, it is possible to find certain problems arising from the improper use of the above concepts, which in turn leads us to stare decisis, a term that if used incorrectly may result in an act against the internal independence of judges. (shrink)

The purpose of this scoping review is to investigate the value of creative arts therapies in healthy older adults. This article aims to shed light on current knowledge concerning the effectiveness of art therapies for the prevention of common age-related conditions using the definition of art therapy provided by the American Art Therapy Association, as well as Cohen’s conceptual framework for the psychological conceptualization of the relationship between the arts and health in later life. The objective is to carefully capture (...) subthreshold situations of distress, which are often not taken into account and primarily involve psychological aspects that are crucial in the multidimensional perspective of healthy aging. Twelve articles were selected and examined following an initial electronic search on 3 databases. A thematic analysis of the results identified four major themes: improving cognitive performance and proprioception; enhancing self-identity and meaningful life; reducing feelings of loneliness and depressive symptoms; and the importance of socialization. All these aspects constitute the basis for preventing psychological distress and enhancing mental well-being for healthy aging. (shrink)

El presente trabajo es el resultado de mi participación en el evento de discusión de la revista Problema. Anuario de Filosofía y Teoría del Derecho, que llevó por nombre “La construcción del precedente en el Civil Law: debates, conceptos y desafíos”, en el cual participaron varios colegas con un amplio conocimiento en el tema del precedente judicial; de igual forma, ahonda en los temas de mayor debate dentro de lo referente al precedente judicial, enfocado al caso chileno. Todo ello, con (...) la finalidad de proponer algunas soluciones al respecto, así como dilucidar ciertos aspectos importantes dentro del precedente. Partiendo de conceptos tan trascendentes como la prescriptibilidad, la racionalidad y el uso argumentativo, se logra llegar a ciertas problemáticas provocadas por el mal uso de los conceptos previamente mencionados, que a su vez nos conduce al stare decisis, término que mal utilizado puede resultar en un acto contrario a la independencia interna de la cual gozan los jueces. (shrink)

Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this early (...) step of muscle regeneration exacerbates inflammation at later stages, compromises neo‐angiogenesis and the growth of newly formed myofibers, and reduces post‐injury muscle force production. Platelets also contribute to the recruitment of pro‐regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease. (shrink)

El metaverso, como nuevo espacio prometido de interacción social, no configura en sí mismo la posibilidad del encuentro, porque no es el espacio lo que propicia el “entre” sino la disposición de las personas. Por ello en este artículo se dirige la mirada al interior del ser humano y se centra en la reflexión ética del ser en el estar; precisamente, porque toda herramienta configura un nuevo ethos con el sujeto. En primer lugar, tras problematizar la pregunta por el metaverso, (...) se desarrolla el concepto de relación social, para pasar, en segundo lugar, al espacio como configurador de la utopía y a la pregunta de cómo el ser humano se construye en lo que él mismo crea. De esta manera, se llega al último punto, en el que se plantea que la promesa del metaverso no guarda en sí misma la posibilidad de ser mejores personas, sino que, en cuanto herramienta, depende exclusivamente del uso que se le dé. (shrink)

En este escrito se presentan algunos desarrollos de la teoría política de John Rawls ahondando en aquellas categorías que permitan contrastar aspectos de los planteamientos rawlsianos con spectos del pensamiento utilitarista clásico. El propósito es discernir qué tan grande es la deuda que tienen pensadores contemporáneos como Rawls con autores clásicos del siglo XIX tales como Bentham y Mill.

RESUMEN: La muerte del hombre anunciada por Foucault está en estrecha relación con la muerte de Dios anunciada por Nietzsche. El retorno del lenguaje conlleva la desaparición del hombre como figura cardinal del saber moderno. La historia es discontinua. Foucault dudó de las verdades de cada época y de las verdades intemporales. En este artículo trazo el recorrido del hombre en Les mots et les choses, mostrando la tensión entre el lenguaje y la desaparición del hombre, hablo de la discontinuidad (...) de la historia y los “jeux de vérité”, y muestro que Foucault se consideraba, por encima de todo, un pensador escéptico. / ABSTRACT: The death of man proclaimed by Foucault is in close relationship with the death of God proclaimed by Nietzsche. The return of language is linked with the disappearance of man. History is discontinuos. Foucault doubted the truths of each era as well as the timeless truths. In this article I present man’s journey in Foucault’s Les mots et les choses, showing the tension between language and the disappearance of man, I talk about historical discontinuity and the “jeux de vérité”, and I argue that Foucault considered himself, above all, a skeptical thinker. (shrink)

La nouvelle édition des Éléments de rythmanalyse et autres essais sur les temporalités, parue grâce à Claire Revol en 2019 chez Eterotopia, vient d'être traduite en portugais par Flávia Martins, professeur de géographie à l'UFF, et Michel Moreaux, docteur en géographie de l'UERJ. L'ouvrage est publié par l'éditeur Consequência. Cette préface est une invitation à la lecture des Éléments de rythmanalyse : introduction à la connaissance des rythmes, d'Henri Lefebvre. Nous souhaitons que cette œuvre aux multiples - Sociologie – Nouvel (...) article. (shrink)

“There`s only beauty if there is an interlocutor. The beauty of the lagoon is always someone” (Mãe, 2017, p.40). Valter Hugo Mãe expresses our desire in the making of this paper to share our experience of meeting refugee children, as part of an ongoing research project dedicated to exploring the conditions in which they live in Baixada Fluminense, Rio de Janeiro, Brazil, and the influences they bring with them from their birth countries. In the process of conducting this research, we (...) were surprised by a group of children who belong to the Warao ethnic group, and who have been welcomed by the municipality of Nova Iguaçu, which is part of Baixada Fluminense. The Warao are indigenous peoples from the North of Venezuela and their name means “canoe,” given their close relationship with water. A group of displaced Warao children and their families arrived in Nova Iguaçu after having “camped” out in the surroundings of Novo Rio bus station for a few weeks, followed by a sojourn in a public shelter, where the differences between them and the existing members of the institution led to conflict. Through a religious institution’s initiative, the families then found shelter in a small farm in the city of Japeri. They stayed there for six months, but once again were threatened by the prospect of eviction, after which they were finally welcomed in the city of Nova Iguaçu. The families–five interconnected units–expressed the wish to remain together and a social service institution found them a closed school building, which was modified to accommodate the group. When the Covid pandemic struck, the research and study group GEPELID began following the daily routine of these children at the shelter school and at the Marambaia welfare center. In their meetings with the Warao, the researchers were struck by their references to the Buriti tree as the “tree of life,” and the depths of its implications for their identity. In exploring this concept, the research group’s experience of radical cultural difference revealed the extent to which research in the human sciences is always a meeting with the other, and the relation between researcher and subjects an occasion for dialogue. (shrink)

El presente escrito se propone mostrar por qué Heidegger, luego del fracaso de su proyecto inicial, presenta la obra de arte como lugar en el que se esencia la verdad. Más específicamente, propone descubrir por qué el arte permite la superación de la idea de mundo propia de la filosofía moderna y de la ciencia. Para esto, se mostrará por qué la noción de tierra es crucial, como sustracción ocultante, y que es neurálgica para que la verdad se esencie, y (...) posibilite, así, la superación de la idea de mundo como objeto. (shrink)

In the Eudemian Ethics Aristotle states that human beings are starting points of things that could be otherwise and that the eph’hemin are this kind of things. Famously, in the Nicomachean Ethics Aristotle endorses the thesis of habits’ unidirectionality, according to which the agent who already possesses moral habits, hexeis, will perform only actions consistent with the habits she possesses. Despite this apparent inconsistency, I aim to show that the two texts can be harmonized and that the Eudemian Ethics can (...) actually provide a theoretical background for habits’ unidirectionality. (shrink)